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Scientists Want to Make a Lysergic Acid Factory from Microbes

  • Posted on June 21, 2011 at 4:44 pm

Lysergic acid Scientists Want to Make a Lysergic Acid Factory from Microbes

The headline for The Guardian article about this says the scientists want to make LSD (lysergic acid diethylamide), but the article itself says they want to make lysergic acid (with no diethylamide), a precursor to LSD with other uses.

They said developing biofuels was a terrible business strategy, because fuel was so cheap. Why not make expensive compounds, like pharmaceuticals, instead?

The advice got Wintermute thinking. What was the most valuable compound they could make with the toolkit of synthetic biology? Some research came up with a few candidates including a few very sophisticated cancer drugs. But another compound was up there in monetary terms: LSD. The value by weight was astronomical.

Wintermute and his colleagues had a good laugh about that. But the more they looked into it, the more interesting – and viable – the drug looked. Around 20 tonnes of lysergic acid, a precursor of LSD, are made each year and turned into real medicines, such as nicergoline, a treatment for dementia. The drug is purified from big vats of fungus (which make the compound naturally) using technology developed decades ago.

The Guardian: Harvard scientists to make LSD factory from microbes

(via DrBenway23)

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RIP Owsley “Bear” Stanley, Original Sound Engineer for the Grateful Dead and Big Time LSD Manufacturer

  • Posted on March 17, 2011 at 11:07 am

thebear RIP Owsley “Bear” Stanley, Original Sound Engineer for the Grateful Dead and Big Time LSD Manufacturer

Owsley “Bear” Stanley, the original sound engineer for the Greatful Dead who was also credited with kickstarting the 60s by manufacturing massive amounts of LSD, died in a car accident in Australia last weekend.

National Post’s Obituary of Stanley

The Dead get a bad rap these days. Many have forgotten the band’s contributions outside of hippie music. Jerry Garcia, a lifelong science fiction fan, was actually a technology advocate with an interest fringe science ideas like cryogenics. Lyricist John Perry Barlow went on to co-found the EFF. The Dead forum was a core part of the important BBS The WELL, an early force bringing together counter-culture and high technology. In the history of cyberculture, the Dead is up there with Stewart Brand and Timothy Leary in terms of importance.

A couple years ago Uriah Zebadiah hipped me to the Dead’s contributions to audio technology via Stanley. In addition to being an LSD manufacturer, Stanley wanted to experiment with audio technology – and the Grateful Dead were his lab. He funded the band just so he could experiment with their equipment.

From San Francisco Chronicle’s profile of Stanley from 2007 (via Boing Boing):

Less well known are Bear’s contributions to rock concert sound. As the original sound mixer for the Grateful Dead, he was responsible for fundamental advances in audio technology, things as basic now as monitor speakers that allow vocalists to hear themselves onstage. [...]

“We’d never thought about high-quality PAs,” says the Dead’s Weir. “There was no such thing until Bear started making one.”

The Chronicle profile includes a rare interview with Stanley about his all-meat diet and his belief in a coming Ice Age.

For more history of LSD, check out the Skilluminati article Ronald Hadley Stark: The Man Behind the LSD Curtain.

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